TOP GUIDELINES OF PKRRATING

The interfacial residues are highly conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements show which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations guidance a model where activating RNA serves like a scaffold to bind multiple PKR monomers, growing the area

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